RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
H19
RNA ID
RNA Type
lncrna
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
PCR; Masson's trichrome staining etc.
Target
DUSP5
Pathway
MAPK SIGNALING PATHWAY
PubMed ID
Title
Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis
Year
2016
Function
"H19 endogenous expression is overexpressed in cardiac fibroblast and fibrosis tissues, and an opposite pattern is observed for Dusp5. H19 ectopic overexpression reduces Dusp5 abundance and increases the proliferation of cardiac fibroblast, whereas h19 silencing causes the opposite effects."